There have been several fall out issues that stem from JENKINS-8754 (see the issues linked from that), and some critical fixes such as JENKINS-15587 is just getting into 1.507.
This ticket is clearly related to this, but it just doesn't have enough details for us to act on.
Because many of those issues have been fixed since this issue has been reported, I'm marking this closed as INCOMPLETE.
If you continue to see problems post 1.507, please open separate tickets and include the stack trace from the server console output, as well as your OS and whether the symlink support is enabled.
Same problem here when upgrading from 1.480 to 1.483