Upgraded to 2.222.3 and encountered the error after second Jenkins reboot.

[Due to restriction from my end, i can not share the log file as a whole, so adding exception encountered in the comment itself]

com.thoughtworks.xstream.mapper.CannotResolveClassException: hudson.plugins.active_directory.ActiveDirectorySecurityRealm
at com.thoughtworks.xstream.mapper.DefaultMapper.realClass(DefaultMapper.java:79)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.DynamicProxyMapper.realClass(DynamicProxyMapper.java:55)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.PackageAliasingMapper.realClass(PackageAliasingMapper.java:88)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.ClassAliasingMapper.realClass(ClassAliasingMapper.java:79)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.ArrayMapper.realClass(ArrayMapper.java:74)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.SecurityMapper.realClass(SecurityMapper.java:71)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at hudson.util.XStream2$CompatibilityMapper.realClass(XStream2.java:379)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at hudson.util.xstream.MapperDelegate.realClass(MapperDelegate.java:43)
at com.thoughtworks.xstream.mapper.MapperWrapper.realClass(MapperWrapper.java:30)
at com.thoughtworks.xstream.mapper.CachingMapper.realClass(CachingMapper.java:48)
at hudson.util.RobustReflectionConverter.determineType(RobustReflectionConverter.java:458)
at hudson.util.RobustReflectionConverter.doUnmarshal(RobustReflectionConverter.java:324)
Caused: jenkins.util.xstream.CriticalXStreamException: hudson.plugins.active_directory.ActiveDirectorySecurityRealm : hudson.plugins.active_directory.ActiveDirectorySecurityRealm
---- Debugging information ----
message : hudson.plugins.active_directory.ActiveDirectorySecurityRealm
cause-exception : com.thoughtworks.xstream.mapper.CannotResolveClassException
cause-message : hudson.plugins.active_directory.ActiveDirectorySecurityRealm
class : hudson.model.Hudson
required-type : hudson.model.Hudson
converter-type : hudson.util.RobustReflectionConverter
path : /hudson/securityRealm
line number : 121
version : not available
-------------------------------
at hudson.util.RobustReflectionConverter.doUnmarshal(RobustReflectionConverter.java:353)
at hudson.util.RobustReflectionConverter.unmarshal(RobustReflectionConverter.java:267)
at com.thoughtworks.xstream.core.TreeUnmarshaller.convert(TreeUnmarshaller.java:72)
at com.thoughtworks.xstream.core.AbstractReferenceUnmarshaller.convert(AbstractReferenceUnmarshaller.java:65)
at com.thoughtworks.xstream.core.TreeUnmarshaller.convertAnother(TreeUnmarshaller.java:66)
at com.thoughtworks.xstream.core.TreeUnmarshaller.convertAnother(TreeUnmarshaller.java:50)
at com.thoughtworks.xstream.core.TreeUnmarshaller.start(TreeUnmarshaller.java:134)
at com.thoughtworks.xstream.core.AbstractTreeMarshallingStrategy.unmarshal(AbstractTreeMarshallingStrategy.java:32)
at com.thoughtworks.xstream.XStream.unmarshal(XStream.java:1189)
at hudson.util.XStream2.unmarshal(XStream2.java:161)
at hudson.util.XStream2.unmarshal(XStream2.java:132)
at com.thoughtworks.xstream.XStream.unmarshal(XStream.java:1173)
at hudson.XmlFile.unmarshal(XmlFile.java:180)
Caused: java.io.IOException: Unable to read E:\Program Files (x86)\Jenkins\config.xml
at hudson.XmlFile.unmarshal(XmlFile.java:183)
at hudson.XmlFile.unmarshal(XmlFile.java:163)
at jenkins.model.Jenkins.loadConfig(Jenkins.java:3118)
at jenkins.model.Jenkins.access$1200(Jenkins.java:320)
at jenkins.model.Jenkins$13.run(Jenkins.java:3219)
at org.jvnet.hudson.reactor.TaskGraphBuilder$TaskImpl.run(TaskGraphBuilder.java:169)
at org.jvnet.hudson.reactor.Reactor.runTask(Reactor.java:296)
at jenkins.model.Jenkins$5.runTask(Jenkins.java:1133)
at org.jvnet.hudson.reactor.Reactor$2.run(Reactor.java:214)
at org.jvnet.hudson.reactor.Reactor$Node.run(Reactor.java:117)
at jenkins.security.ImpersonatingExecutorService$1.run(ImpersonatingExecutorService.java:59)
at java.util.concurrent.ThreadPoolExecutor.runWorker(Unknown Source)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(Unknown Source)
at java.lang.Thread.run(Unknown Source)
Caused: org.jvnet.hudson.reactor.ReactorException
at org.jvnet.hudson.reactor.Reactor.execute(Reactor.java:282)
at jenkins.InitReactorRunner.run(InitReactorRunner.java:50)
at jenkins.model.Jenkins.executeReactor(Jenkins.java:1166)
at jenkins.model.Jenkins.<init>(Jenkins.java:966)
at hudson.model.Hudson.<init>(Hudson.java:85)
at hudson.model.Hudson.<init>(Hudson.java:81)
at hudson.WebAppMain$3.run(WebAppMain.java:233)
Caused: hudson.util.HudsonFailedToLoad
at hudson.WebAppMain$3.run(WebAppMain.java:250)