We have upgraded to Jenkins version 2.277.4 and found that when we click on build button, it is showing error as "Page not working." PFA image for reference. This seems to be an intermittent issue. 

The same issue is found when we click on Save button or apply button after changing the configuration  of Job. I tried upgrading to latest version 2.289.1 still the issue didnot get fixed. 

Below are the workaround i tried.
1. Upgraded to latest stable version of Jenkins
2.Tried upgrading or degrading certain plugins like active choice plugin , HTML publisher , HTTP Request. 
3. Removed Job config history plugin completely.

But None of this helped get the problem fixed.