If the help button is not aligned to an object, for example a header, it's placed somewhere below the section it belongs to instead of right next to it:

For reference, that's how it used to look on 2.263.3

The same can be obtained at the notification URL dropdown:

Compared to 2.263.3:

Even if that is placed by a plugin, the same issue applies here too.

This is a regression of the help button modernization, I didn't take a look yet which version this has been introduced in, however, it's present on 2.332.1 and could possibly be an lts candidate, once addressed.